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KDDF-201402-01 Development of intranasal insulin using TCTP-PTD(Metabolic Disorders, Protein) [06.02.2014]

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Development and Market Objectives

Our goal is to develop an alternative non-invasive method of insulin administration for diabetic patients who are treated with insulin injection. We are currently optimizing a nasal insulin candidate based on TCTP-PTD, originating from TCTP (translationally controlled tumor protein) which can facilitate the nasal delivery of insulin.

Unmet Medical Need & Target Patients

Patients receiving long-term insulin therapy with invasive hypodermic injections can become averse to treatment due to pain, fear and issues related to discomfort. In addition, repeated injections can cause side effects including abnormal absorption and infections arising from skin damage. In particular, children and the elderly experience difficulty in self-administration using injectors. Therefore, the development of more user-friendly methods of insulin administration, alternative routes of insulin administration, is needed. 

Status

Using various analogues of TCTP-PTD, the lead optimization and pre-formulation study of a nasal insulin is underway.

Intellectual Property

 [A composition for improving of insulin transmucosal ability] - Patent registered in Korea (2015) 
 [A peptide with ability to penetrate plasma membrane] – Patent application filed in Korea (2016)

Competitive Advantages

Unlike PTDs derived from other virus or transcription factors, TCTP-PTD (which is derived from human protein, TCTP), is expected to be a safe and versatile approach for intranasal or noninvasive delivery of bioactive molecules such as insulin. Nasal delivery of insulin using TCTP-PTD may serve the user-friendly medications that are safe and effective for the treatment of diabetes, thereby improving the clinical usefulness of insulin therapy.

Indication

Metabolic Disorders (Diabetes)

Research Period

May 01, 2014 - Dec. 31, 2016

Company

Ewha Womans University

Developmental Stage

Lead Generation & Lead optimization

Additional Information

Contact Information

Contact
Address Company Name: College of Pharmacy Ewha Womans University
WebSite Homepage: http://home.ewha.ac.kr/~pharm21/ Contact Person: Ms. Jeehye Maeng
E-mail: mengjeehye@hanmail.net Contact: +82-2-3277-3018

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