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KDDF-201606-17 Anticancer drug based on oncolytic adenovirus with enhanced cancer cell killing and immune activation(Oncology, Genetics) [11.01.2016]

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Development and Market Objectives

Development of oncolytic adenovirus as anti-cancer drug with both of tumor versatility and selectivity by combining of genes acting co-operatively like organic complex

 

Unmet Medical Need & Target Patients

- Cancer patients with liver cancer and melanoma as a proof of concept. However, shRNAs complex in the drug can facilitate the application to other types of cancer with the help of delivery and targeting.

- After several trials of efficacy comparisons between sorafenib and various drugs to hepatocellular carcinoma (HCC) or various drugs to sorafenib-resistant HCC patients in clinical trial phase 3, all trials were proven to be failed. So, an urgent consensus for the development of liver cancer drug is broadly spreaded.

Status

-In vivo efficacy and toxicity

-Formation of various candidates of armed oncolytic adenovirus

-Investigation of action mechanisms of combined shRNAs

Intellectual Property

Priority application for Korea(10-2016-0166171) and PCT application were completed(PCT/KR2016/014325).

Competitive Advantages

-Arming of multiple genes in addition to GM-CSF versus single gene (GM-CSF) - much stronger antitumor effect without toxicity

-Minimizing of immune suppressive effect derived from tumor microenvironment by shRNA

Indication

Oncology

Research Period

2016.9.20-2017.9.19

Company

Yonsei University

Developmental Stage

Generation

Additional Information

Contact Information

Contact
Address Company Name: Yonsei University, College of Medicine, Severance Biomedical Science Institute
WebSite Homepage: http://sbsi.yuhs.ac/kor/people Contact Person: Prof. Jae Jin Song
E-mail: jjs109@yuhs.ac Contact: +82-2-2228-8037

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