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KDDF-201601-03 Discovery of PDK4 inhibitors(Metabolic Disorders, Chemical) [08.25.2016]

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Development and Market Objectives

The aim of our research is to develop a first-in-class PDK4 (pyruvate dehydrogenase kinase 4, which promote effectively glucose disposal in mitochondria) inhibitor candidate to treat a diabetic patient who needs a treatment with a new mechanism of action.

Unmet Medical Need & Target Patients

Currently available antidiabetic drugs are still challenged by substantial adverse effects or weak points (injection, hypoglycemia, and other side effects).

Even though, these medications are effective toward only less than 50% diabetes patients who reach HbA1c < 6.5.

Therefore, there is a need to develop a new drug candidate with a new mechanism of action, particularly by improving mitochondria action.

PDK4 inhibitor can be a new treatment option for diabetic patient who fails to adequately control hyperglycemia by current existing drugs.

Status

Identifying the several PDK4 hit/lead compounds

Confirming the potential of PDK4 active compounds in in vivo model

Validating the lead compounds having the good pharmacokinetic profile and anti-diabetic efficacy in long-term in vivo models

Intellectual Property

Patent filed in Korea (2015) 
Patent filed in PCT (2015)

Competitive Advantages

1) Improve diabetes by promoting effectively glucose disposal in mitochondria

2) First-in-class target for diabetic drugs

3) Additional therapeutic potential for allergy treatment as PDK4 inhibitor

Indication

Diabetes

Research Period

Jul. 1, 2016 ~ Jun. 30, 2018

Company

Gwangju Institute of Science and Technology, Department of Chemistry

Developmental Stage

Generation

Additional Information

Contact Information

Contact
Address Company Name: Gwangju Institute of Science and Technology, Department of Chemistry
WebSite Homepage: http://https://sites.google.com/site/medichemgist1 Contact Person: Bae EunJung
E-mail: helloimej@gist.ac.kr Contact: +82-10-2804-0170

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