Completed Projects

HOME > R&D Pipeline > Current status > Completed Projects

KDDF-201512-06 Development of novel anti-cancer drug targeting p34, a novel modulator of NEDD4-1-mediated PTEN ubiquitination(Oncology, Chemical) [04.18.2016]

PRINT

Development and Market Objectives

The lead compound generation of the first-in-class novel anticancer drug through PTEN activation by inhibiting the interaction between p34 and NEDD4-1 protein

Unmet Medical Need & Target Patients

Colon cancer is a serious disease where recurrence rate is 20~50% even after curative resection of colorectal cancer. Targeted treatments in colon cancer patients with Erbitux, which targets the EGFR but these drugs do not show potential efficacy on all patient groups

The novel anti-cancer drugs target groups of colon cancer patients with p34 and NEDD4-1 double positives along with PTEN wild type patients exhibiting the mutant KRAS or the wild KRAS not responsive to Erbitux treatment.

Status

Biological studies of NEDD4-1/p34 interaction for clarifying exact mechanism of PTEN activation

Complex structure study and new hit generation using virtual screening

Structure & modeling guided synthesis of hit derivatives

in vitro, in vivo efficacy evaluation for hit derivatives

Intellectual Property

Domestic and PCT Patents were published in the major countries

Patents for the selected compounds are filed.

Competitive Advantages

Due to the first-in-class target mechanism, thus, first-in-class drug, it is likely to become an effective global drug for colon cancer patients exhibiting the mutant KRAS (about 40%) or the wild KRAS not responsive to Erbitux treatment (about 30%).

Indication

Oncology

Research Period

2016.4.1-2017.5.31

Company

Chodang Pharmaceuticals

Developmental Stage

Generation

Additional Information

Contact Information

Contact
Address Company Name: Chodang Pharmaceuticals
WebSite Homepage: http://www.chodang.com Contact Person: Hyedong Yoo, Heejong Lee
E-mail: hdyoo@chodang.com, leehj@chodang.com Contact: +82-2-853-0585

Related Projects

Related Project
list
Update to 2013 © KOREA DRUG DEVELOPMENT FUND. ALL RIGHTS RESERVED. QR Code